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Date: 26 September 1988 / 28 September 1988
Heats
Quarter-finals
Semi-finals
Final
| Rank | Name | Nation | Time |
| 1 | Joe Deloach | USA | 19.75 |
| 2 | Carl Lewis | USA | 19.79 |
| 3 | Robson da Silva | BRA | 20.04 |
| 4 | Linford Christie | GBR | 20.09 |
| 5 | Atlee Mahorn | CAN | 20.39 |
| 6 | Gilles Queneherve | FRA | 20.40 |
| 7 | Michael Rosswess | GBR | 20.51 |
| 8 | Bruno Marie-Rose | FRA | 20.58 |
| Semi-finals | |||
| 9 | Cyprian Enweani | CAN | 20.57 |
| 10 | Stefano Tilli | ITA | 20.59 |
| 11 | Roy Martin | USA | 20.62 |
| 12 | Olapade Adeniken | NGR | 20.67 |
| 13 | John Regis | GBR | 20.69 |
| 14 | Edgardo Guilbe | PUR | 20.77 |
| 15 | Troy Douglas | BER | 20.84 |
| 16 | Ralf Lubke | FRG | 21.23 |
| Quarter-finals | |||
| 17 | Kennedy Ondiek | KEN | 20.79 |
| 18 | Luis Barroso | POR | 20.81 |
| 18 | Clive Wright | JAM | 20.81 |
| 18 | Daniel Sangouma | FRA | 20.81 |
| 21 | Kenji Yamauchi | JPN | 20.94 |
| 21 | Patrick Stevens | BEL | 20.94 |
| 23 | John Myles-Mills | GHA | 20.95 |
| 24 | Norbert Dobeleit | FRG | 20.98 |
| 25 | Isiaq Adeyanju | NGR | 21.01 |
| 26 | Mark Garner | AUS | 21.08 |
| 27 | Courtney Brown | CAN | 21.18 |
| 28 | Attila Kovacs | HUN | 21.19 |
| 29 | Jimmy Flemming | ISV | 21.23 |
| 30 | Mustafa Kamel Selmi | ALG | 21.26 |
| 31 | Lee Shiunn-Long | TPE | 21.34 |
| 32 | Harouna Pale | BUR | 21.35 |
| 32 | Chang Jae-Keun | KOR | 21.35 |
| 34 | Li Feng | CHN | 21.38 |
| 35 | Samuel Nchinda-Kaya | CMR | 21.39 |
| 36 | Andreas Berger | AUT | 21.40 |
| 37 | Ousmane Diarra | MLI | 21.46 |
| 38 | Ibrahim Tamba | SEN | 21.93 |
| 39 | Oliver Daniels | LBR | 22.25 |
| 40 | Pietro Mennea | ITA | |
| Heats | |||
| 41 | Fabian Muyaba | ZIM | 21.66 |
| 41 | Henri Ndinga | CGO | 21.66 |
| 43 | Wing-Kwong Leung | HKG | 21.69 |
| 44 | Luis Cunha | POR | 21.72 |
| 45 | Issa Alassane-Ousseni | BEN | 21.74 |
| 46 | Lindel Hodge | IVB | 21.78 |
| 46 | Howard Lindsay | ANT | 21.78 |
| 48 | Sunday Olweny | UGA | 21.79 |
| 49 | Abdullah Al-Khalidi | OMA | 21.82 |
| 50 | Yousef Aouf Abdi Rahman | IRQ | 21.88 |
| 50 | Andre Francois | VIN | 21.88 |
| 52 | Muhammad Afzal | PAK | 21.89 |
| 53 | Takale Tuna | PNG | 21.95 |
| 54 | Henrico Atkins | BAR | 21.98 |
| 55 | Jerry Jeremiah | VAN | 22.01 |
| 56 | Markus Buchel | LIE | 22.02 |
| 57 | Mohamed Al-Bishi | KSA | 22.09 |
| 58 | Abdallah Ali Ahmed | LBA | 22.11 |
| 59 | Carlos Moreno | CHI | 22.13 |
| 60 | Alexandre Yougbare | BUR | 22.14 |
| 61 | Odiya Silweya | MAW | 22.24 |
| 62 | Gustavo Envela | GEQ | 22.33 |
| 63 | Maloni Bole | FIJ | 22.44 |
| 64 | Peauope Suli | TGA | 22.49 |
| 65 | Mohamed Shah Alam | BAN | 22.52 |
| 66 | Claude Roumain | HAI | 22.60 |
| 67 | Dinh Minh Nguyen | VIE | 22.65 |
| 68 | Robert Loua | GUI | 22.78 |
| 69 | Benny Kgarametso | BOT | 22.79 |
| 70 | Sahim Saleh Mehdi | YMD | 22.95 |
| 71 | Ismail Asif | MDV | 23.17 |
| Disqualified | |||
| Armenio Gaspar Fernandes | ANG | ||
| Did not start | |||
| Samuel Birch | LBR | ||
| Simeon Kipkemboi | KEN | ||
| Boevi Lawson | TOG | ||